The NeuroWire Virtual Club at Laval University brings together neuroscientists across the world to discuss novel findings in the field of neural circuits through an open virtual forum. Organized by Dr. Lisa Topolnik, professor at the Neuroscience Axis of the CRCHUQ-Laval University Research Centre, the NeuroWire Club is hosting numerous virtual events ranging from expert talks to group debates with leaders in the neural circuit field to discuss recent discoveries and identify new challenging directions.

Join the club to stay connected and receive Zoom links for all upcoming events.

Virtual club

February 25
10-00 to 11-00 EST

Balázs Rózsa
Institute of Experimental Medicine, Hungary
https://rozsalab.eu/

Sharp-wave ripple events induce complex dendritic spikes in parvalbumin interneurons in behaving mice

Neuronal plasticity has been shown to be causally linked to coincidence detection through dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch-specific, local dSpikes and their computational role in hippocampal PV+ interneurons in awake animals.
To measure long thin dendrites during SPW-Rs, we used fast 3D acousto-optical imaging through an eccentric deep-brain adapter and focal electropysiological recordings. This unique combination enabled, for the first time, fast access to long, thin dendritic segments simultaneously in multiple locations along the entire 3D dendritic arbour of the PV+ cells during locally-detected SPW-R events in awake mice, with orders-of-magnitude higher speed and better signal-to-noise ratio than previous two-dimensional imaging methods.
Our approach revealed the existence of SPW-R-dSpikes which were initiated in a minority of dendrites in distal dendritic regions at variable, NMDA-AMPA-dependent, hot-spots and propagated at a high amplitude beyond a sharp distance threshold (~150 µm).
A novel supralinear summation emerged during SPW-R doublets when two successive SPW-R events coincide within a short temporal window (~150 ms), e.g. during more complex association tasks. Our results indicate that doublet-associated dSpikes are the smallest computational unit in the brain functioning as a coincidence detector during SPW-R-related computation.

Upcoming talks

March 4
10-00 to 11-00 EST

Steven Prescott
University of Toronto, SickKids, Canada
http://prescottlab.ca/

March 11
10-00 to 11-00 EST

Elsa Rossignol
University of Montreal, CHU Sainte-Justine Research Center, Canada
https://www.chusj.org/Bio?id=5b83741d-1d9c-447f-8498-c8f3f5cc3126&lang=en

March 18
10-00 to 11-00 EST

​Ivo Spiegel
Weizmann Institute of Science, Israel
https://www.weizmann.ac.il/neurobiology/labs/spiegel/welcome

March 25
10-00 to 11-00 EST

Derek Bowie
McGill University, Canada
http://www.medicine.mcgill.ca/pharma/dbowielab/

April 8
10-00 to 11-00 EST

Frances K Skinner
Krembil Research Institute, Canada
https://www.skinnerlab.org/

April 15
10-00 to 11-00 EST

Alexey Semyanov
IBCH RAS, Russia
http://www.ibch.ru/structure/groups/ext​

April 22
10-00 to 11-00 EST

April 29
10-00 to 11-00 EST

Sylvain Crochet
Ecole polytechnique fédérale de Lausanne, Switzerland
https://people.epfl.ch/sylvain.crochet

Project Coordinators:

Parisa Iloun
parisa.iloun.1@ulaval.ca
PhD student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

Luca Pancotti
luca.pancotti.1@ulaval.ca
PhD student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

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NeuroWire Virtual Club!