The NeuroWire Virtual Club brings together neuroscientists across the world to discuss novel findings in the field of neural circuits through an open virtual forum. Organized by Drs. Lisa Topolnik, professor at the Neuroscience Axis of the CRCHUQ-Laval University Research Centre, and Benedicte Amilhon, professor at the Department of Neurosciences and Sainte-Justine Research Centre at Université de Montreal, NeuroWire Club is hosting numerous virtual events ranging from expert talks to group debates with leaders in the neural circuit field to discuss recent discoveries and identify new challenging directions.

Join the club to stay connected and receive Zoom links for all upcoming events.

Virtual club

September 16
10-00 to 11-00 EST

Simon Chen
University of Ottawa, Canada
https://med.uottawa.ca/cellular-molecular/people/chen-simon

Dissecting Neural Circuits Underlying Motor Learning in Normal and Disease Mouse Models

Mammals exhibit an incredible amount of flexibility in motor control, which is believed to be due to the remarkable ability of brain circuits to rapidly undergo structural and functional plasticity to fluidly modifying body movements through learning. Disrupting these processes can often lead to impaired motor learning in both normal and diseased conditions. Our lab research focuses on bridging the gap between cellular and molecular signaling underlying the plasticity of neural circuits involved in motor skill learning. In the first part of the talk, I will present our current work, in which we revealed a critical role of a functional distinct NPAS4-expressing somatostatin- interneuron ensemble in motor learning, using chronic in vivo two-photon imaging in head-fixed behaving mice. In the second part of the talk, I will present a recently published work from the lab, in which we examined mice with a syntenic deletion of chromosome 16p11.2, a common copy number variation associated with ASD. We found 16p11.2 deletion mice display a delay in motor learning, which reminiscent of the motor learning-related deficits in children with ASD, without showing gross movement deficits. In addition, we identified a dysfunctional locus coeruleus noradrenergic (LC-NA) neuromodulatory system that leads to abnormal structural and functional changes in the motor cortex, which resulted in delayed motor learning in the 16p11.2 deletion mice.
Refereed publications

Upcoming talks

September 30
10-00 to 11-00 EST

Michele Giugliano
Scuola Internazionale Superiore di Studi Avanzati (SISSA), Italy
http://phdneurobiology.sissa.it/eng/faculty/michele-giugliano

October 7
10-00 to 11-00 EST

Rebecca Piskorowski
Paris Descartes University, France
https://ipnp.paris5.inserm.fr

October 14
10-00 to 11-00 EST

Vikaas Sohal
UCSF Weill Institute for Neurosciences, USA
https://profiles.ucsf.edu/vikaas.sohal

October 21
10-00 to 11-00 EST

Romain Goutagny
The European Neuroscience Institute at Strasbourg, France
https://www.eni-net.org/members/dr-romain-goutagny/

October 28
10-00 to 11-00 EST

Jayeeta Basu
New York University Neuroscience Institute, USA
https://med.nyu.edu/faculty/jayeeta-basu

November 4
10-00 to 11-00 EST

Jesper Sjöström
McGill University, Canada
https://www.mcgill.ca/crn/research/sjostrom

November 25
10-00 to 11-00 EST

December 2
10-00 to 11-00 EST

Sylvain Williams
Douglas Institute – McGill University, Canada
https://sylvainwilliams.ca/

December 16
10-00 to 11-00 EST

Jean-Claude Lacaille
Université de Montréal, Canada
https://neurosciences.umontreal.ca/jean-claude-lacaille/

January 6
10-00 to 11-00 EST

Project Coordinators:

Parisa Iloun
parisa.iloun.1@ulaval.ca
PhD student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

Félix Michaud
felix.michaud.2@ulaval.ca
Master student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

Eve Honore
eve.honore@umontreal.ca
PhD student
Laboratory of Jean-Claude
Lacaille
Faculté de médecine de l’Université de Montréal
Canada

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NeuroWire Virtual Club!