The NeuroWire Virtual Club brings together neuroscientists across the world to discuss novel findings in the field of neural circuits through an open virtual forum. Organized by Drs. Lisa Topolnik, professor at the Neuroscience Axis of the CRCHUQ-Laval University Research Centre, and Benedicte Amilhon, professor at the Department of Neurosciences and Sainte-Justine Research Centre at Université de Montreal, NeuroWire Club is hosting numerous virtual events ranging from expert talks to group debates with leaders in the neural circuit field to discuss recent discoveries and identify new challenging directions.

Join the club to stay connected and receive Zoom links for all upcoming events.

Virtual club

January 27, 2022
10-00 to 11-00 EST

Gautam Awatramani
University of Victoria, Canada https://www.uvic.ca/profiles/gautam-awatramani

Function follows Form or Form follows function? Lessons from the retinal direction-selective circuit

Understanding how the brain computes information requires a deep understanding of how neuronal types within specified circuits are connected, as well as a detailed description of the functional properties of those connections.
Recent advances in molecular, neurochemical, and/or anatomical techniques have led to an explosion in the number of known excitatory and inhibitory neuronal types in any given region of the brain, emphasizing the challenge of any endeavor to understand computations. 

In this seminar, I will describe how we have approached this problem in the retina, where we have focussed on a single neural circuit: the direction-selective circuit. I will discuss how connectomic studies combined with single synapse functional analysis can be used to provide an unprecedently detailed view of how activity from diverse cell types is combined to compute specific information. 

Specifically, I will highlight 1) how the kinetic properties of distinct glutamatergic bipolar cells that are arranged stereotypically along the radiating dendrites of GABAergic/cholinergic starburst amacrine cells, contribute to their direction selectivity. 2) How the starburst amacrine cell, in turn, drives direction selectivity in downstream ganglion cells, relying on high synapse specificity and distinct spatiotemporal profiles of GABA and cholinergic transmission.

Refereed publications

Upcoming talks

February 3
10-00 to 11-00 EST

Michaël Zugaro
Collège de France, INSERM, France
http://zugarolab.net

February 10
10-00 to 11-00 EST

Linda Katona
University of Oxford, UK
https://www.pharm.ox.ac.uk/team/linda-katona

February 17
10-00 to 11-00 EST

Annalisa Scimemi
University of Albany, USA
https://www.albany.edu/biology/faculty/annalisa-scimemi

February 24
10-00 to 11-00 EST

Ivan Soltesz
Stanford University, USA
https://profiles.stanford.edu/ivan-soltesz

March 3
10-00 to 11-00 EST

Mazen Kheirbek
University of California San Francisco, USA
https://profiles.ucsf.edu/mazen.kheirbek

March 10
10-00 to 11-00 EST

Etay Hay
CAMH/Krembil, University of Toronto, Canada
https://www.camh.ca/en/science-and-research/etayhay

March 17
10-00 to 11-00 EST

Jean-Claude Béïque
University of Ottawa, Canada
https://www.uottawa.ca/brain/people/beique-jean-claude

March 24
10-00 to 11-00 EST

Xiaolong Jiang
Baylor College of Medicine, USA
https://www.bcm.edu/people-search/xiaolong-jiang

March 31
10-00 to 11-00 EST

Massimo Avoli
McGill University, Canada
https://www.mcgill.ca/neuro/research/researchers/avoli

April 7
10-00 to 11-00 EST

Jeremiah Cohen
Johns Hopkins University, USA
https://cohenlab.johnshopkins.edu/

April 14
10-00 to 11-00 EST

Robert R. Rozeske
University of Toronto, Canada
https://www.rozeskelab.org

May 5
10-00 to 11-00 EST

Lisa Roux
IINS, Université de Bordeaux, France
https://www.iins.u-bordeaux.fr/roux

Connect with
NeuroWire Virtual Club!

Project Coordinators:

Parisa Iloun
parisa.iloun.1@ulaval.ca
PhD student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

Félix Michaud
felix.michaud.2@ulaval.ca
Master student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada

Eve Honore
eve.honore@umontreal.ca
PhD student
Laboratory of Jean-Claude
Lacaille
Faculté de médecine de l’Université de Montréal
Canada

Suhel Tamboli
suhel.tamboli.1@ulaval.ca
PhD student
Laboratory of Lisa Topolnik
Neuroscience Axis, CRCHUQ-CHUL
Université Laval
Canada